Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
USERS' SCORE
Good
Based on 28 Reviews
8.2
Supplement Facts
Serving Size: 1 Level Teaspoon (approx. 2 g)
Serving Per Container: About 85
Amount Per Serving
%DV
Calories
10
Total Carbohydrate
2 g
<1%*
Total Sugars
2 g
†
Organic D-Mannose
2 g (2,000 mg)
†
Top Medical Research Studies
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
Most Useful Reviews
9
Cystitis relief
57 people found this helpful
Thanks to the creator, for this is a MIRACLE powder. I've suffered with chronic cystitis for 3 years, experiencing monthly flare-ups. I relied on antibiotics like ciprofloxacin, which destroyed my microflora and led to constant thrush. Desperate for relief, I stumbled upon D-mannose. I ordered a small jar and felt relief after my first dose. I took two capsules morning and evening, and importantly, now, I only need D-mannose after intercourse. My symptoms have lessened significantly, and I no longer suffer from cystitis. I have since ordered larger jars as backups. Why isn’t this product prescribed in Russia? I wish everyone good health!
Read More
9
Stop antibiotics
11 people found this helpful
I recommend this product to anyone enduring chronic cystitis! Tired of wasting money on antibiotics that worked temporarily, I switched to D-Mannose powder, which has kept my condition at bay for 1.5 months. Increased doses help during flare-ups, and I’ve also noticed an improvement in my chronic pyelonephritis. I’m incredibly grateful for this treatment!
Read More
9
Overcame bladder issues
8 people found this helpful
Works brilliantly! After years of bladder problems and reliance on medication, a new urologist recommended D-Mannose and weaned me off Enablex. It truly worked; I can sleep through the night and undertake long drives without needing to stop! Initially, I ordered D-Mannose from the doctor’s site at a steep price, but opting for a more affordable brand yielded the same, if not better, results. I’m so glad I made the switch!
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 5 Researches
8.8
- All Researches
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
Read More
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Read More
9
We explored how engineered antibodies using mannose 6-phosphate analogs can enhance treatment for autoimmune and inflammatory disorders. Through a clever design, these antibodies target both harmful proteins and specific receptors on cells, which allows for greater internalization and degradation of these proteins.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Read More
9
We explored an innovative approach to treating rheumatoid arthritis (RA) using mannose-targeted methotrexate delivery systems. This strategy involved creating chimaeric polymersomes that deliver higher amounts of methotrexate directly to macrophages.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
The results showed that this method led to improved uptake by activated macrophages, promoting a shift towards healthier anti-inflammatory responses. It also reduced the production of harmful cytokines, effectively protecting joint tissues from damage. Overall, mannose-mediated delivery presents a promising enhancement to RA therapy.
Read More
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
Read More
User Reviews
USERS' SCORE
Good
Based on 28 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Cystitis relief
57 people found this helpful
Thanks to the creator, for this is a MIRACLE powder. I've suffered with chronic cystitis for 3 years, experiencing monthly flare-ups. I relied on antibiotics like ciprofloxacin, which destroyed my microflora and led to constant thrush. Desperate for relief, I stumbled upon D-mannose. I ordered a small jar and felt relief after my first dose. I took two capsules morning and evening, and importantly, now, I only need D-mannose after intercourse. My symptoms have lessened significantly, and I no longer suffer from cystitis. I have since ordered larger jars as backups. Why isn’t this product prescribed in Russia? I wish everyone good health!
Read More
9
Stop antibiotics
11 people found this helpful
I recommend this product to anyone enduring chronic cystitis! Tired of wasting money on antibiotics that worked temporarily, I switched to D-Mannose powder, which has kept my condition at bay for 1.5 months. Increased doses help during flare-ups, and I’ve also noticed an improvement in my chronic pyelonephritis. I’m incredibly grateful for this treatment!
Read More
9
Overcame bladder issues
8 people found this helpful
Works brilliantly! After years of bladder problems and reliance on medication, a new urologist recommended D-Mannose and weaned me off Enablex. It truly worked; I can sleep through the night and undertake long drives without needing to stop! Initially, I ordered D-Mannose from the doctor’s site at a steep price, but opting for a more affordable brand yielded the same, if not better, results. I’m so glad I made the switch!
Read More
9
Reduces disease severity
6 people found this helpful
Thanks to mannose, I've been cystitis-free for six months! It lessens the severity of acute symptoms, allowing for milder forms and quicker recovery. I take half a teaspoon daily and increase to a full spoon at the first signs of trouble! Initially, I got a small jar for testing but now I don’t want to run out. An absolute recommendation!
Read More
10
Consistent relief
5 people found this helpful
This is a super product! I first tried it in capsules but found the powder more effective. I take one teaspoon in water, and it has resolved my cystitis issues. I now recommend D-Mannose to everyone experiencing similar problems.
Read More
Frequently Asked Questions
9
Cystitis relief
57 people found this helpful
Thanks to the creator, for this is a MIRACLE powder. I've suffered with chronic cystitis for 3 years, experiencing monthly flare-ups. I relied on antibiotics like ciprofloxacin, which destroyed my microflora and led to constant thrush. Desperate for relief, I stumbled upon D-mannose. I ordered a small jar and felt relief after my first dose. I took two capsules morning and evening, and importantly, now, I only need D-mannose after intercourse. My symptoms have lessened significantly, and I no longer suffer from cystitis. I have since ordered larger jars as backups. Why isn’t this product prescribed in Russia? I wish everyone good health!
7.5
Symptom relief
1 people found this helpful
I've been suffering from chronic cystitis since I was five and now I’m 32. I ordered this hoping for relief. After two days of use, the urethral discomfort has decreased. I’ve finished one jar and bought another; the powder genuinely works. I take it at night during symptoms and the cystitis subsides, offering health benefits as well.
9
Stop antibiotics
11 people found this helpful
I recommend this product to anyone enduring chronic cystitis! Tired of wasting money on antibiotics that worked temporarily, I switched to D-Mannose powder, which has kept my condition at bay for 1.5 months. Increased doses help during flare-ups, and I’ve also noticed an improvement in my chronic pyelonephritis. I’m incredibly grateful for this treatment!
9
Reduces disease severity
6 people found this helpful
Thanks to mannose, I've been cystitis-free for six months! It lessens the severity of acute symptoms, allowing for milder forms and quicker recovery. I take half a teaspoon daily and increase to a full spoon at the first signs of trouble! Initially, I got a small jar for testing but now I don’t want to run out. An absolute recommendation!
1
Use cautiously
4 people found this helpful
Be careful when using this! I purchased D-Mannose expecting relief, but it worsened my situation. Perhaps it was due to the brand or the product itself. I urge anyone to start with a small dosage to avoid severe UTIs.
9
Essential for cystitis
5 people found this helpful
An essential remedy for cystitis! This product is a crucial part of my medicine cabinet since I frequently experience kidney-related issues and cystitis. At the first sign of an attack, I dissolve 1 teaspoon in room temperature water and drink it, up to twice daily, depending on severity. The powder is pleasant, dissolves effortlessly, and sweetens the water. The effects are remarkable—it works swiftly, often on the same day. It's safe, natural, and effective, making it highly recommended for anyone facing similar issues.
9
Prevents relapses
2 people found this helpful
A real salvation from cystitis! I can use this to prevent the first signs of cystitis. For postcoital cystitis, I take a teaspoon immediately after intercourse, and there are no relapses. Prior to this, I faced exacerbations every month or two; now, it's down to once every year and a half. An excellent remedy!
7.5
Cystitis relief achieved
3 people found this helpful
Fantastic product! An alternative to antibiotics. Previously, I ordered mannose capsules for convenience. However, I find the powder works better. Before my period, cystitis flared up; I took a teaspoon with cranberries, and symptoms vanished in a day. After intimacy, I faced no cystitis or discomfort. Whereas E. coli led to vaginitis and antibiotics before, now thanks to D-mannose, there are no issues with vaginitis. It also benefits my intestines, showing greater effects than probiotics.
7.5
Reduced relapses
5 people found this helpful
We have only recently started using this. E. coli often causes my child's cystitis. Previously, nephrologists would prescribe antibiotics endlessly with little effect. Luckily, since we began taking D-Mannose at night alongside other supplements, everything has been going well. It appears to prevent E. coli from adhering to the bladder wall without disrupting beneficial microbes.
9
We examined how D-mannose impacts ulcerative colitis (UC) in a mouse model designed to mimic human inflammatory bowel disease. Our findings reveal that D-mannose significantly lessens UC symptoms by reducing inflammation and oxidative stress. Notably, it increases regulatory T (Treg) cell levels, which are crucial in controlling immune responses. This study is the first to show D-mannose's therapeutic potential for UC, bringing newfound hope for managing this condition.
8
We explored whether d-mannose can help alleviate psoriasis, an autoimmune condition that causes significant discomfort. Our study demonstrated that both oral and topical applications of d-mannose were effective in reducing psoriasis symptoms in mice.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
We discovered that it works by lowering levels of a protein called HIF-1α and the chemokine CCL20 in skin cells. This inhibition interrupts the harmful cycle between keratinocytes and Th17 immune cells. Overall, this suggests d-mannose could be a helpful treatment option for managing psoriasis.
9
We investigated how sodium oligomannate affects autoimmune encephalomyelitis in mice and its role in altering gut bacteria and microglial behavior. Mice were divided into groups, with some receiving varying doses of sodium oligomannate.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
Results showed improved symptoms and reduced disease severity in the treatment groups compared to the control. Specifically, changes in inflammatory markers and gut flora ratios were noted, indicating that higher doses yielded better outcomes.
Overall, sodium oligomannate demonstrated a promising, dose-dependent therapeutic effect on autoimmune disorders.
9
We explored how engineered antibodies using mannose 6-phosphate analogs can enhance treatment for autoimmune and inflammatory disorders. Through a clever design, these antibodies target both harmful proteins and specific receptors on cells, which allows for greater internalization and degradation of these proteins.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
Our studies showed that this new approach greatly increased the effectiveness of antibodies like infliximab and bevacizumab, making them much better at inhibiting their targets. This innovative strategy could pave the way for more effective treatments in autoimmunity and inflammation.
References
- Lu Y, Xiong Y, Zhang S, Wang B, Feng Y, et al. D-mannose reduces oxidative stress, inhibits inflammation, and increases treg cell proportions in mice with ulcerative colitis. Front Pharmacol. 2024;15:1454713. 10.3389/fphar.2024.1454713
- Zhao YL, Li ZX. [Therapeutic potential of EAE mice with sodium oligomannate and effects of intestinal flora and microglia polarization]. Zhonghua Yi Xue Za Zhi. 2024;104:1521. 10.3760/cma.j.cn112137-20231114-01087
- Daurat M, Gauthier C, El Cheikh K, Ali LMA, Morère E, et al. Engineered therapeutic antibodies with mannose 6-phosphate analogues as a tool to degrade extracellular proteins. Front Immunol. 2024;15:1273280. 10.3389/fimmu.2024.1273280
- Jiang Q, Wei B, You M, Zhou X. d-mannose blocks the interaction between keratinocytes and Th17 cells to alleviate psoriasis by inhibiting HIF-1α/CCL20 in mice. Int Immunopharmacol. 2023;118:110087. 10.1016/j.intimp.2023.110087
- Yang L, Sha Y, Wei Y, Fang H, Jiang J, et al. Mannose-mediated nanodelivery of methotrexate to macrophages augments rheumatoid arthritis therapy. Biomater Sci. 2023;11:2211. 10.1039/d2bm02072f
